The pedestrian - an 8 year old girl - was treated by paramedics but was sadly pronounced dead at the scene.
A 24-year-old man was arrested on suspicion of causing death by dangerous driving. He remains in custody for questioning.
Monton Road is currently closed between Cavendish Road and Half Edge Lane.
Enquiries are still ongoing.
Police Sergeant Lee Westhead, of GMP’s Serious Collision Investigation Unit, said:
“Tragically a young child lost her life this morning and we are doing all we can to support her family at this devastating time.
“I would urge anyone who witnessed the collision or anyone with any information to please get in touch with my team on 0161 856 4741.”
“The road closures will remain in place throughout the afternoon as investigative work is carried out so please avoid the area where possible.
Anyone with information should call GMP’s Serious Collision Investigation Unit on 0161 856 4741 quoting reference number of 09/11/2018, or the independent charity Crimestoppers, anonymously, on 0800 555 111.