At 11.50pm on Friday 18 November 2016, a green Skoda Octavia collided with a pedestrian, a 38-year-old woman, on Lower Broughton Road, near to the junction of Frederick Road.
The woman was taken to hospital where she is being treated for a serious head injury and is in a life-threatening condition.
The man driving the Skoda was uninjured.
Police Constable Paul Hailwood of GMP’s Serious Collision Investigation Unit said: “Our thoughts are with the woman’s family at this distressing time.
“We have launched an investigation to establish the circumstances if the collision and I would urge anyone who saw what happened, to get in touch as a matter of urgency.”
Anyone with information is asked to contact the Serious Collision Investigation Unit on 0161 856 4742, or the independent charity Crimestoppers, anonymously, on 0800 555 111.